Phosphatidylserine receptors are critical for lethal infection by Crimean-Congo hemorrhagic fever virus

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1. Apparenté Contexte plus large Pas pertinent

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   Cette étude réduit la protéine PrP par siRNA chez des souris atteintes de maladie à prions, tandis que l’article cible des récepteurs d’entrée du CCHFV.

   En bref

   Chez la souris infectée par des prions, une forte réduction de PrP par siRNA maintient les animaux traités précocement sans symptômes jusqu’à 500 jours après inoculation.

2. Apparenté Même question Pas pertinent

   Ticks on the run: A mathematical model of Crimean-Congo Haemorrhagic Fever (CCHF)-key factors for transmission

   Suman Bhowmick, Khushal Khan Kasi, Jörn Gethmann et al. · 2021 · Biological Physics · cité 23 fois · Résumé IA disponible

   Ce modèle mathématique étudie la transmission du CCHFV par les tiques, tandis que l’article examine les récepteurs nécessaires à son infection et à sa pathogénicité.

   Résumé scientifique

   Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by the Crimean-Congo hemorrhagic fever virus (CCHFV). Ticks belonging to the genus \textit{Hyalomma} are the main vectors and reservoir for the virus. It is maintained in nature in an endemic vertebrate-tick-vertebrate cycle. CCHFV is prevalent in wide geographical areas including Asia, Africa, South-Eastern Europe and the Middle East. Over the last decade, several outbreaks of CCHFV have been observed in Europe, mainly in Mediterranean countries. Due to the high case/fatality ratio of CCHFV in human sometimes, it is of great importance for public health. Climate change and the invasion of CCHFV vectors in Centra…

3. Apparenté Contexte plus large Pas pertinent

   Mathematical Modeling of CRISPR-CAS system effects on biofilm formation

   Qasim Ali, Lindi Wahl · 2016 · Populations and Evolution · cité 6 fois · Résumé IA disponible

   Ce modèle porte sur les effets de CRISPR-Cas sur les biofilms bactériens, sans étudier le CCHFV ni ses récepteurs d’entrée.

   Résumé scientifique

   Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), linked with CRISPR associated (CAS) genes, play a profound role in the interactions between phage and their bacterial hosts. It is now well understood that CRISPR-CAS systems can confer adaptive immunity against bacteriophage infections. However, the possibility of failure of CRISPR immunity may lead to a productive infection by the phage (cell lysis) or lysogeny. Recently, CRISPR-CAS genes have been implicated in changes to group behaviour, including biofilm formation, of the bacterium Pseudomonas aeruginosa when lysogenized. For lysogens with a CRISPR system, another recent experimental study suggests that bacteriophage re…

4. Apparenté Contexte plus large Pas pertinent

   Killing of targets by effector CD8$^+$T cells in the mouse spleen follows the law of mass action

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   Résumé scientifique

   It has been difficult to measure efficacy of T cell-based vaccines and to correlate efficacy of CD8$^+$T cell responses with protection against viral infections. In part, this difficulty is due to our poor understanding of the in vivo efficacy of CD8$^+$T cells. Using a recently developed experimental method of in vivo cytotoxicity we investigated quantitative aspects of killing of peptide-pulsed targets by effector and memory CD8$^+$T cells, specific to three epitopes of lymphocytic choriomeningitis virus (LCMV), in the mouse spleen. By analyzing data on killing of targets with varying number of epitope-specific effector and memory CD8$^+$T cells, we find that killing of targets by effector…

5. Apparenté Autre approche du problème Pas pertinent

   Quantifying the Sensitivity of HIV-1 Viral Entry to Receptor and Coreceptor Expression

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   Résumé scientifique

   Infection by many viruses begins with fusion of viral and cellular lipid membranes, followed by entry of viral contents into the target cell and ultimately, after many biochemical steps, integration of viral DNA into that of the host cell. The early steps of membrane fusion and viral capsid entry are mediated by adsorption to the cell surface, and receptor and coreceptor binding. HIV-1 specifically targets CD4+ helper T-cells of the human immune system and binds to the receptor CD4 and coreceptor CCR5 before fusion is initiated. Previous experiments have been performed using a cell line (293-Affinofile) in which the expression of CD4 and CCR5 concentration were independently controlled. Afte…

6. Apparenté Contexte plus large Pas pertinent

   The role of parasite-produced dopamine in Toxoplasma gondii-altered host behaviour

   Beatriz Calvo-Urbano, Maya Kaushik, An-Chi Cheng et al. · 2025 · Nature Communications · cité 2 fois · Résumé IA disponible

   Cette étude examine la dopamine produite par Toxoplasma gondii et les changements comportementaux de l’hôte, sans porter sur l’entrée virale.

   Résumé scientifique

   Abstract Certain parasites appear to manipulate their host’s behaviour for their own selective benefit. The mechanisms behind such behavioural alterations in vertebrate hosts remain elusive, despite their profound implications, particularly for those parasites with a broad host range. Toxoplasma gondii , the causative agent of the globally important toxoplasmosis, is a canonical example for parasite-altered behaviour in its rodent intermediate host. Such behavioural alterations, from subtle to severe, are also displayed across a broad spectrum of infected secondary hosts, including humans. Dopamine dysregulation has been proposed as one potential mechanistic explanation. Furthermore, T. gond…

7. Apparenté Contexte plus large Pas pertinent

   Increased adaptive immune responses and proper feedback regulation protect against clinical dengue

   Etienne Simon-Loriere, Veasna Duong, Ahmed Tawfik et al. · 2017 · Science Translational Medicine, American Association for the Advancement of Science, 2017, 9 (405), pp.eaal5088 · cité 82 fois · Résumé IA disponible

   Cette étude compare les réponses immunitaires lors d’infections par la dengue, tandis que l’article évalue des facteurs d’entrée et la maladie due au CCHFV.

   Résumé scientifique

   Dengue is the most prevalent arthropod-borne viral disease. Clinical symptoms of dengue virus (DENV) infection range from classical mild dengue fever to severe, life-threatening dengue shock syndrome. However, most DENV infections cause few or no symptoms. Asymptomatic DENV-infected patients provide a unique opportunity to decipher the host immune responses leading to virus elimination without negative impact on t v 'health. We used an integrated approach of transcriptional profiling and immunological analysis comparing a Cambodian population of strictly asymptomatic viremic individuals with clinical dengue patients. Whereas inflammatory pathways and innate immune responses were similar betw…

8. Apparenté Contexte plus large Pas pertinent

   A parasitoid overcomes collective defense by silencing host communication

   Z.-W. Wang, C. Ye, Y. Zhong et al. · 2026 · bioRxiv preprint · Résumé IA disponible

   Cette étude montre comment une guêpe parasitoïde supprime l’alarme des pucerons, un mécanisme d’interaction hôte-parasite distinct de l’infection par le CCHFV.

   En bref

   La guêpe parasitoïde Ephedrus lacertosus inhibe la libération de phéromone d’alarme des pucerons grâce à deux protéines venimeuses, désorganisant leur défense collective et favorisant le parasitisme.