Phosphatidylserine receptors are critical for lethal infection by Crimean-Congo hemorrhagic fever virus

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   PrP-lowering siRNA suppresses prion replication and disease in mice, whereas this paper tests phosphatidylserine receptors in CCHFV infection and disease.

   In short

   Deep PrP lowering with a C16-conjugated siRNA prevented symptoms through 500 days in prion-infected mice treated early and extended survival when treatment began after symptoms.

2. Related Same question Not relevant

   Ticks on the run: A mathematical model of Crimean-Congo Haemorrhagic Fever (CCHF)-key factors for transmission

   Suman Bhowmick, Khushal Khan Kasi, Jörn Gethmann et al. · 2021 · Biological Physics · cited 23 times · AI summary available

   This model examines factors governing CCHFV transmission among ticks and vertebrates, while this paper tests host receptors affecting CCHFV infection and disease.

   Abstract

   Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by the Crimean-Congo hemorrhagic fever virus (CCHFV). Ticks belonging to the genus \textit{Hyalomma} are the main vectors and reservoir for the virus. It is maintained in nature in an endemic vertebrate-tick-vertebrate cycle. CCHFV is prevalent in wide geographical areas including Asia, Africa, South-Eastern Europe and the Middle East. Over the last decade, several outbreaks of CCHFV have been observed in Europe, mainly in Mediterranean countries. Due to the high case/fatality ratio of CCHFV in human sometimes, it is of great importance for public health. Climate change and the invasion of CCHFV vectors in Centra…

3. Related Broader context Not relevant

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   Qasim Ali, Lindi Wahl · 2016 · Populations and Evolution · cited 6 times · AI summary available

   This model concerns CRISPR-Cas effects on bacterial biofilm formation, while this paper uses CRISPR screens to identify CCHFV host-entry factors.

   Abstract

   Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), linked with CRISPR associated (CAS) genes, play a profound role in the interactions between phage and their bacterial hosts. It is now well understood that CRISPR-CAS systems can confer adaptive immunity against bacteriophage infections. However, the possibility of failure of CRISPR immunity may lead to a productive infection by the phage (cell lysis) or lysogeny. Recently, CRISPR-CAS genes have been implicated in changes to group behaviour, including biofilm formation, of the bacterium Pseudomonas aeruginosa when lysogenized. For lysogens with a CRISPR system, another recent experimental study suggests that bacteriophage re…

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   Vitaly V. Ganusov, Daniel L. Barber, Rob J. De Boer · 2009 · Quantitative Methods · preprint, not peer reviewed · cited 2 times · AI summary available

   This study quantifies CD8 T-cell killing of LCMV-target cells in mouse spleen, rather than receptor-dependent CCHFV entry and disease.

   Abstract

   It has been difficult to measure efficacy of T cell-based vaccines and to correlate efficacy of CD8$^+$T cell responses with protection against viral infections. In part, this difficulty is due to our poor understanding of the in vivo efficacy of CD8$^+$T cells. Using a recently developed experimental method of in vivo cytotoxicity we investigated quantitative aspects of killing of peptide-pulsed targets by effector and memory CD8$^+$T cells, specific to three epitopes of lymphocytic choriomeningitis virus (LCMV), in the mouse spleen. By analyzing data on killing of targets with varying number of epitope-specific effector and memory CD8$^+$T cells, we find that killing of targets by effector…

5. Related Another approach to the problem Not relevant

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   This study quantifies how CD4 and CCR5 expression affects HIV-1 entry, while this paper tests phosphatidylserine receptors in CCHFV entry.

   Abstract

   Infection by many viruses begins with fusion of viral and cellular lipid membranes, followed by entry of viral contents into the target cell and ultimately, after many biochemical steps, integration of viral DNA into that of the host cell. The early steps of membrane fusion and viral capsid entry are mediated by adsorption to the cell surface, and receptor and coreceptor binding. HIV-1 specifically targets CD4+ helper T-cells of the human immune system and binds to the receptor CD4 and coreceptor CCR5 before fusion is initiated. Previous experiments have been performed using a cell line (293-Affinofile) in which the expression of CD4 and CCR5 concentration were independently controlled. Afte…

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   This study considers dopamine as a mechanism for Toxoplasma-altered host behaviour, unlike this paper’s focus on host receptors in viral infection.

   In short

   In rats, greater parasite TgTH expression was associated with stronger Toxoplasma gondii-related behavioural changes, supporting a contributory role for TgTH.

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   Increased adaptive immune responses and proper feedback regulation protect against clinical dengue

   Etienne Simon-Loriere, Veasna Duong, Ahmed Tawfik et al. · 2017 · Science Translational Medicine, American Association for the Advancement of Science, 2017, 9 (405), pp.eaal5088 · cited 82 times · AI summary available

   This study compares immune responses in asymptomatic and clinical dengue, while this paper investigates phosphatidylserine receptors in CCHFV infection and pathogenesis.

   Abstract

   Dengue is the most prevalent arthropod-borne viral disease. Clinical symptoms of dengue virus (DENV) infection range from classical mild dengue fever to severe, life-threatening dengue shock syndrome. However, most DENV infections cause few or no symptoms. Asymptomatic DENV-infected patients provide a unique opportunity to decipher the host immune responses leading to virus elimination without negative impact on t v 'health. We used an integrated approach of transcriptional profiling and immunological analysis comparing a Cambodian population of strictly asymptomatic viremic individuals with clinical dengue patients. Whereas inflammatory pathways and innate immune responses were similar betw…

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   A parasitoid overcomes collective defense by silencing host communication

   Z.-W. Wang, C. Ye, Y. Zhong et al. · 2026 · bioRxiv preprint · AI summary available

   This study shows a parasitoid suppressing aphid alarm communication, whereas this paper examines host receptors that enable viral infection.

   In short

   The parasitoid wasp Ephedrus lacertosus uses two venom proteins to suppress aphid alarm pheromone release, disrupting collective escape responses and promoting parasitism.