Endothelial protein C receptor is an entry receptor for Langya virus
How to prepare an accurate paper press kit? Illustrated guide
Y.-J. Park, J. Song, R. Gen, C. Stewart, S. Lee, D. Veesler · DOI: 10.64898/2026.11.04.763901 · Summary page
Why cover this story this week?
A cellular doorway for Langya virus
Researchers have identified endothelial protein C receptor, or EPCR, as a receptor that Langya virus can use to enter human cells. The preprint combines receptor-entry experiments with molecular analysis of how the virus’s attachment protein binds EPCR. It also maps features that help explain which species’ versions of the receptor the virus can use.
Human and shrew EPCR supported cell entry by Langya virus and by pseudoviruses representing the related Mojiang virus. Together with reports of related viruses in shrews, the findings help distinguish this group from henipaviruses associated with fruit bats. A known cellular doorway gives surveillance teams a more specific property to investigate in newly discovered viruses and provides a target for countermeasure research. Receptor compatibility alone, however, does not establish how readily a virus spreads between hosts or causes disease.
Editorial context written by AI from abstracts, not independent scientific validation. The kit and its verified quotes rely on the source paper, not on this letter.
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