Investigating Voice as a Biomarker for leucine-rich repeat kinase 2-Associated Parkinson's Disease
Authors: S. Arora, N. P. Visanji, T. A. Mestre, A. Tsanas, A. AlDakheel, B. S. Connolly, C. Gasca-Salas, D. S. Kern, J. Jain, E. J. Slow, A. Faust-Socher, A. E. Lang, M. A. Little, C. Marras
Abstract: We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts
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