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MEGA-RAG: a retrieval-augmented generation framework with multi-evidence guided answer refinement for mitigating hallucinations of LLMs in public health
Shan Xu (Fudan University, China Academy of Information and Communications Technology), Zhaokun Yan (China Academy of Information and Communications Technology), Chengxiao Dai (The University of Sydney, China Academy of Information and Communications Technology), Fan Wu (Fudan University)
Abstract: Introduction: The increasing adoption of large language models (LLMs) in public health has raised significant concerns about hallucinations-factually inaccurate or misleading outputs that can compromise clinical communication and policy decisions. Methods: We propose a retrieval-augmented generation framework with multi-evidence guided answer refinement (MEGA-RAG), specifically designed to mitigate hallucinations in public health applications. The framework integrates multi-source evidence retrieval (dense retrieval via FAISS, keyword-based retrieval via BM25, and biomedical knowledge graphs), employs a cross-encoder reranker to ensure semantic relevance, and incorporates a discrepancy-aware refinement module to further enhance factual accuracy. Results: Experimental evaluation demonstrates that MEGA-RAG outperforms four baseline models [PubMedBERT, PubMedGPT, standalone LLM, and LLM with standard retrieval-augmented generation (RAG)], achieving a reduction in hallucination rates by over 40%. It also achieves the highest accuracy (0.7913), precision (0.7541), recall (0.8304), and F1 score (0.7904). Discussion: These findings confirm that MEGA-RAG is highly effective in generating factually reliable and medically accurate responses, thereby enhancing the credibility of AI-generated health information for applications in health education, clinical communication, and evidence-based policy development.