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Commentary: High-metastatic melanoma cells promote the metastatic capability of low-metastatic melanoma cells via exosomal transfer of miR-411-5p
Tianhang Li (Nanjing Drum Tower Hospital, Nanjing University), Hongqian Guo (Nanjing Drum Tower Hospital, Nanjing University), Rong Li Yang (Nanjing Drum Tower Hospital, Nanjing University)
Abstract: Exosome-encapsulated bioactive molecules are known to play a pivotal role in modulating a variety of malignant biological behaviors, especially metastasis.Due to its high content fidelity, long-distance transportation capacity, and abundant material loading capabilities, the exosome has been verified as a good trainer for the formation of a premetastatic niche with a range of protumoral features.Recently, a study by Chen et al. demonstrated a unique function exerted by melanoma cancer cells to enhance metastatic capability through exosomal transfer from high-metastatic cells to low-metastatic cells (1).This is a very interesting article, which enriches and expands the functions and mechanisms of exosomes in cancer.Our team previously published a hypothesis article in the journal (2), whose topic has a tight connection with this research, and we are very Frontiers in Oncology frontiersin.