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Toxoplasma gondiiinfection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?
Joanne P. Webster (Imperial College London), Maya Kaushik (Imperial College London), Greg C. Bristow (University of Leeds), Glenn A. McConkey (University of Leeds)
Abstract: We examine the role of the protozoan Toxoplasma gondii as a manipulatory parasite and question what role study of infections in its natural intermediate rodent hosts and other secondary hosts, including humans, may elucidate in terms of the epidemiology, evolution and clinical applications of infection. In particular, we focus on the potential association between T. gondii and schizophrenia. We introduce the novel term 'T. gondii-rat manipulation-schizophrenia model' and propose how future behavioural research on this model should be performed from a biological, clinical and ethically appropriate perspective.