Running summarizing tools on a new article

Check the paper below, then start its synthesis.


Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

Vancheswaran Gopalakrishnan (The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston), C. N. Spencer (The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston), Luigi Nezi (The University of Texas MD Anderson Cancer Center), Alexandre Reuben (The University of Texas MD Anderson Cancer Center), Miles Cameron Andrews (The University of Texas MD Anderson Cancer Center), Tatiana V. Karpinets (The University of Texas MD Anderson Cancer Center), Peter A. Prieto (The University of Texas MD Anderson Cancer Center), Diego A. Vicente (The University of Texas MD Anderson Cancer Center), Kristi Louise Hoffman (The University of Texas MD Anderson Cancer Center), Spencer C. Wei (The University of Texas MD Anderson Cancer Center), Alexandria P. Cogdill (The University of Texas MD Anderson Cancer Center), L. Zhao (The University of Texas MD Anderson Cancer Center), Courtney W. Hudgens (The University of Texas MD Anderson Cancer Center), Diane S. Hutchinson (Baylor College of Medicine), Teresa Manzo (The University of Texas MD Anderson Cancer Center), Mariana Petaccia de Macêdo (The University of Texas MD Anderson Cancer Center), Tiziana Cotechini (Oregon Health & Science University), Tapsi Kumar (The University of Texas MD Anderson Cancer Center), W. S. Chen (The University of Texas MD Anderson Cancer Center), Sangeetha Meda Reddy (The University of Texas MD Anderson Cancer Center), Robert A. Szczepaniak Sloane (The University of Texas MD Anderson Cancer Center), Jessica Galloway-Peña (The University of Texas MD Anderson Cancer Center), Hong Jiang (The University of Texas MD Anderson Cancer Center), Pei-Ling Chen (The University of Texas MD Anderson Cancer Center), Elizabeth J. Shpall (The University of Texas MD Anderson Cancer Center), Katayoun Rezvani (The University of Texas MD Anderson Cancer Center), Amin Majid Alousi (The University of Texas MD Anderson Cancer Center), Roy F. Chemaly (The University of Texas MD Anderson Cancer Center), Samuel A. Shelburne (The University of Texas MD Anderson Cancer Center), Luis M. Vence (The University of Texas MD Anderson Cancer Center), Pablo C. Okhuysen (The University of Texas MD Anderson Cancer Center), Vanessa Behrana Jensen (The University of Texas MD Anderson Cancer Center), Alton G. Swennes (Baylor College of Medicine), Florencia M. McAllister (The University of Texas MD Anderson Cancer Center), Erick Marcelo Riquelme (The University of Texas MD Anderson Cancer Center), Yexi Zhang (The University of Texas MD Anderson Cancer Center), Emmanuelle Le Chatelier (Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Institut National de la Recherche Agronomique), Laurence Zitvogel (Institut Gustave Roussy), Nicolas Pons (Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Institut National de la Recherche Agronomique), Jacob L. Austin-Breneman (The University of Texas MD Anderson Cancer Center), Lauren Elaine Haydu (The University of Texas MD Anderson Cancer Center), Elizabeth M. Burton (The University of Texas MD Anderson Cancer Center), Julie M. Gardner (The University of Texas MD Anderson Cancer Center), Elizabeth Sirmans (The University of Texas MD Anderson Cancer Center), Jiemiao Hu (The University of Texas MD Anderson Cancer Center), Alexander J. Lazar (The University of Texas MD Anderson Cancer Center), Takahiro Tsujikawa (Oregon Health & Science University), Adi K. Diab (The University of Texas MD Anderson Cancer Center), Hussein A. Tawbi (The University of Texas MD Anderson Cancer Center), Isabella C. Glitza (The University of Texas MD Anderson Cancer Center), Wen‐Jen Hwu (The University of Texas MD Anderson Cancer Center), Sapna Pradyuman Patel (The University of Texas MD Anderson Cancer Center), Scott Eric Woodman (The University of Texas MD Anderson Cancer Center), Rodabe Navroze Amaria (The University of Texas MD Anderson Cancer Center), Michael A. Davies (The University of Texas MD Anderson Cancer Center), Jeffrey E. Gershenwald (The University of Texas MD Anderson Cancer Center), Patrick Hwu (The University of Texas MD Anderson Cancer Center), J. E. Lee (The University of Texas MD Anderson Cancer Center), J. Zhang (The University of Texas MD Anderson Cancer Center), Lisa M. Coussens (Oregon Health & Science University), Zachary Aaron Cooper (The University of Texas MD Anderson Cancer Center), P. Andrew Futreal (The University of Texas MD Anderson Cancer Center), Carrie R. Daniel (The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston), Nadim J. Ajami (Baylor College of Medicine), Joseph F. Petrosino (Baylor College of Medicine), Michael T. Tetzlaff (The University of Texas MD Anderson Cancer Center), Padmanee Sharma (The University of Texas MD Anderson Cancer Center), James Patrick Allison (The University of Texas MD Anderson Cancer Center), Robert R. Jenq (The University of Texas MD Anderson Cancer Center), Jennifer Ann Wargo (The University of Texas MD Anderson Cancer Center)

Science
License: not stated (all rights reserved)

Abstract: Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade. They profiled samples from patients with lung and kidney cancers and found that nonresponding patients had low levels of the bacterium Akkermansia muciniphila . Oral supplementation of the bacteria to antibiotic-treated mice restored the response to immunotherapy. Matson et al. and Gopalakrishnan et al. studied melanoma patients receiving PD-1 blockade and found a greater abundance of “good” bacteria in the guts of responding patients. Nonresponders had an imbalance in gut flora composition, which correlated with impaired immune cell activity. Thus, maintaining healthy gut flora could help patients combat cancer. Science , this issue p. 91 , p. 104 , p. 97 ; see also p. 32

Published on 02 Nov. 2017