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Gut microbiota shapes cancer immunotherapy responses
Wanting Lei (Army Medical University, Sichuan University), Kexun Zhou (Sichuan University, West China Hospital of Sichuan University), Ye Lei (Neijiang Normal University), Qiu Li (Sichuan University, West China Medical Center of Sichuan University), Hong Zhu (Sichuan University, West China Medical Center of Sichuan University)
Abstract: The gut microbiota significantly influences cancer immunotherapy efficacy by modulating immune responses, remodeling the tumor microenvironment (TME), and producing key metabolites. Strategies such as FMT, probiotics, and dietary interventions show promise in enhancing responses to ICIs and ACTs while reducing immune-related adverse events (irAEs). This review summarizes clinical and preclinical findings and discusses microbiota-based interventions and future directions for precision immunotherapy.