Running summarizing tools on a new article
Check the paper below, then start its synthesis.
Human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution
Theresa M. Schütze (Center for Regenerative Therapies Dresden, Technische Universität Dresden), Annika Kolodziejczyk (Center for Regenerative Therapies Dresden, Technische Universität Dresden), Nora Ditzer (Center for Regenerative Therapies Dresden, Technische Universität Dresden), Silvia Vangelisti (Helmholtz Munich), Emanuele Capra (Human Technopole), Jeong-Eun Lee (Center for Regenerative Therapies Dresden, Technische Universität Dresden), Ilaria Chiaradia (MRC Laboratory of Molecular Biology), Vida Kufrin (Helmholtz-Zentrum Dresden-Rossendorf, University Hospital Carl Gustav Carus), Seiya Yamada (University of Helsinki, HiLIFE – Elämäntieteiden Instituutti), Jula Peters (Max Planck Institute of Molecular Cell Biology and Genetics), Maximilian Krause (DRESDEN-concept Genome Center, Center for Molecular and Cellular Bioengineering), Christina Eugster Oegema (Max Planck Institute of Molecular Cell Biology and Genetics), Răzvan Petru Derihaci (Nationales Centrum für Tumorerkrankungen Dresden, Technische Universität Dresden), Cahit Birdir (University Hospital Heidelberg, Technische Universität Dresden), Takashi Namba (University of Helsinki, Fujita Health University), Alexander Arthur Wurm (Helmholtz-Zentrum Dresden-Rossendorf, University Hospital Carl Gustav Carus), Ulrich Martin (Medizinische Hochschule Hannover, Research Center for Translational Regenerative Medicine), Pauline Wimberger (Nationales Centrum für Tumorerkrankungen Dresden, Technische Universität Dresden), Katherine R. Long (King's College London, MRC Centre for Neurodevelopmental Disorders), Madeline A. Lancaster (MRC Laboratory of Molecular Biology), Nereo Kalebic (Human Technopole), Boyan Bonev (Helmholtz Munich), Mareike Albert (Center for Regenerative Therapies Dresden, Technische Universität Dresden)
Abstract: As the seat of our cognition, the human neocortex is an object of immense fascination. Human neocortex expansion during evolution has been attributed to an increase in the proliferative capacity of neural progenitor cells during development, particularly basal radial glia. Despite their evolutionary relevance, the genomic changes driving human basal radial glia biology remain uncharacterised. We use comparative chromatin and transcriptional profiling of neural progenitor cells isolated from gorilla, chimpanzee and human cerebral organoids to identify cis-regulatory elements that have gained activity in humans. Focusing specifically on basal radial glia, we discover that morphoregulatory enhancer activity and gene expression signatures distinguish human basal radial glia from other great apes. Functional analysis of the morphoregulatory genes FAM107A and CNGA3 in human organoids reveals that these genes contribute to the morphological complexity of human basal radial glia. Taken together, our inter-species comparison of basal radial glia suggests that human-specific morphoregulatory signatures characterise neocortex evolution.