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A microbiome-reactive TMIGD2hi Th17 subset is spatially enriched at the intestinal epithelium and expanded in inflammatory bowel disease

Thomas K. Pedersen (Broad Institute, Technical University of Denmark), Tanvi Jain (Broad Institute, Klarman Cell Observatory), Åsa Segerstolpe (Broad Institute, Klarman Cell Observatory), Crystal Lin (Broad Institute, Klarman Cell Observatory), Angela R. Shih (Harvard University, Massachusetts General Hospital), Luezhen Yuan (Broad Institute, Klarman Cell Observatory), Orr Ashenberg (Broad Institute, Klarman Cell Observatory), Marco Emilio Kaper (Harvard University, Massachusetts General Hospital), Shaina W. Twardus (Harvard University, Massachusetts General Hospital), Rocco Ricciardi (Harvard University, Massachusetts General Hospital), Helena Lau (Broad Institute, Harvard University), James J. Moon (Harvard University, Massachusetts General Hospital), Susanne Brix (Technical University of Denmark), Ramnik J. Xavier (Broad Institute, Brigham and Women's Hospital), Daniel B. Graham (Broad Institute, Harvard University)

Immunity
DOI: 10.1016/j.immuni.2026.09.026 (Immunology and Microbiology)
License: not stated (all rights reserved)
Published on 01 Oct. 2026