A brain signature highly predictive of future progression to Alzheimer's dementia
Authors: Christian Dansereau, Angela Tam, AmanPreet Badhwar, Sebastian Urchs, Pierre Orban, Pedro Rosa-Neto, Pierre Bellec
Abstract: Early prognosis of Alzheimer's dementia is hard. Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction of MCI individuals will progress to dementia, even when screened using biomarkers. We propose here to identify a subset of individuals who share a common brain signature highly predictive of oncoming dementia. This signature was composed of brain atrophy and functional dysconnectivity and discovered using a machine learning model in patients suffering from dementia. The model recognized the same brain signature in MCI individuals, 90% of which progressed to dementia within three years. This result is a marked improvement on the state-of-the-art in prognostic precision, while the brain signature still identified 47% of all MCI progressors. We thus discovered a sizable MCI subpopulation which represents an excellent recruitment target for clinical trials at the prodromal stage of Alzheimer's disease.
Tools for this paper
Ask questions about this paper to our AI assistant
You can also chat with multiple papers at once here.
⚠The license of the paper does not allow us to build upon its content and the AI assistant only knows about the paper metadata rather than the full article.
The previous summary was created more than a year ago and can be re-run (if necessary) by clicking on the Run button below.
⚠The license of this specific paper does not allow us to build upon its content and the summarizing tools will be run using the paper metadata rather than the full article. However, it still does a good job, and you can also try our tools on papers with more open licenses.
Look for similar papers (in beta version)
We compare the title and abstract with papers indexed in our database. For arXiv papers, we search within the same category; for DOI and other sources, we search across sources and subjects. You can rerun the search as our database grows.
Disclaimer: The AI-based summarization tool and virtual assistant provided on this website may not always provide accurate and complete summaries or responses. We encourage you to carefully review and evaluate the generated content to ensure its quality and relevance to your needs.