DPYD links glial lipids and myelination to sleep duration

Classés selon la proximité de leur titre et de leur résumé avec ceux de cet article. Sélectionnez-en pour les lire ensemble.

Les articles les plus proches

1. Proche Contexte plus large Pas pertinent

   Developmental sleep during lethargus is associated with metabolic homeostasis and heritable adaptive responses to infection in Caenorhabditis elegans.

   Bynedi Sheshatri Chinna Mounish, Kannan Srilekha, Ramesh Anand et al. · 2026 · Biochemical and Biophysical Research Communications - BBRC · Pas encore résumé

   Cette étude perturbe le sommeil développemental chez C. elegans et examine ses liens avec le métabolisme lipidique, sans étudier DPYD ni la myélinisation.

   Résumé scientifique

   Sleep is a fundamental physiological state essential for metabolic and neuronal homeostasis; however, its contribution to lipid and energy metabolism during development remains incompletely understood. Here, we used Caenorhabditis elegans to investigate the metabolic significance of Developmentally Timed Sleep (DTS). Lethargus-associated DTS was mechanically disrupted using 1 kHz piezoelectric buzzer-induced mechanical stimulation, followed by behavioural, physiological, metabolic and molecular analyses. DTS disruption was associated with reduced behavioural quiescence, altered sleep-associated gene expression, reduced survival and elevated oxidative stress. Notably, disruption during the L4…

2. Apparenté* Contexte plus large Pas pertinent

   Neurofibromin Regulates Sleep Consolidation via Cholinergic Neurons in a Drosophila Model of Neurofibromatosis 1

   Kalliopi Atsoniou, Eirini-Maria Georganta, K. Pfeifer et al. · 2026 · bioRxiv · preprint, non relu par les pairs · Pas encore résumé

   Cette étude relie la consolidation du sommeil aux neurones cholinergiques dans un modèle drosophile de neurofibromatose, plutôt qu’aux lipides gliaux et à DPYD.

3. Apparenté Contexte plus large Pas pertinent

   A novel function of neuroligin 3 : Beyond sociality, Regulating lifespan in Drosophila

   J. Kurbaj, R. Ataei, AF Simon · 2026 · bioRxiv · preprint, non relu par les pairs · Pas encore résumé

   Cette étude examine les effets de Nlg3 sur le sommeil, le comportement social et la longévité chez la drosophile, sans analyser le mécanisme glial de DPYD.

   Résumé scientifique

   Neuroligins are conserved postsynaptic adhesion proteins involved in synaptic function and behaviour. In Drosophila melanogaster, Neuroligin 3 (Nlg3) regulates social behaviour, sleep and synaptic architecture. We now report, through analysis of publicly available transcriptomics data, confirmed with RT-qPCR data, that loss-of-function of the nlg3 gene downregulates the expression of longevity-associated genes foxo, hsp70s, and hsp68. Graded genetic manipulation of the Drosophila melanogaster neuroligin 3 (nlg3) gene indeed modulates both social spacing and lifespan. Specifically, reduced nlg3 expression (via heterozygous deletion, or transposable-element insertion) extends lifespan in both …

4. Apparenté Contexte plus large Pas pertinent

   Analysis of the Influence Between Glymphatic System and Sleep Disorder

   Zi-Xuan Jing · 2026 · Theoretical and Natural Science · Pas encore résumé

   Cette analyse décrit les relations entre sommeil et clairance glymphatique, tandis que l’article étudie la régulation du sommeil par les lipides gliaux et la myéline.

   Résumé scientifique

   The glymphatic system, first described in 2012 by Iliff and Nedergaard's team, is a macroscopic waste clearance pathway in the central nervous system, and plays an essential role in maintaining brain homeostasis by facilitating the convective exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF) to remove neurotoxic solutes. Its functionality is inseparably linked to the physiological state of sleep, with clearance rates dramatically upregulated during non-rapid eye movement (NREM) sleep. Conversely, sleep disturbances, including sleep fragmentation, chronic insomnia, and obstructive sleep apnea (OSA), impair glymphatic function, leading to the accumulation of neurotoxic protei…

5. Apparenté Article de revue Pas pertinent

   Sleep and circadian regulation of DNA repair and retrotransposons in neuronal genome stability and neurodegenerative disease mechanisms

   Abhas Rajhans, Ella Kye, Vedant Balu et al. · 2026 · Frontiers in Neuroscience · Pas encore résumé

   Cette revue synthétise les liens entre sommeil, rythmes circadiens et stabilité du génome neuronal, sans traiter le mécanisme lipidique glial de DPYD.

   Résumé scientifique

   Sleep and wake are fundamental brain states that coordinate diverse physiological processes required for long-term health and survival. Recent research in molecular neuroscience and chronobiology has begun to clarify how sleep–wake cycles and circadian timing intersect with genomic maintenance mechanisms in the nervous system. In this Review, we summarize current evidence that sleep and circadian rhythms temporally regulate neuronal genome stability, with a particular focus on how they modulate neuronal retrotransposon activity. We discuss circadian clock-dependent regulation of DNA repair pathways, the contribution of sleep to chromosomal integrity and chromosome dynamics, and emerging data…

6. Apparenté Contexte plus large Pas pertinent

   The human-specific gene FRMPD2B couples postnatal experience to the expansion of cortical connectivity

   E. Christopoulou, J. Zamith, P. Bonadonna et al. · 2026 · bioRxiv preprint · Résumé IA disponible

   Cette étude porte sur FRMPD2B et le développement des connexions corticales humaines, un sujet distinct de la régulation gliale du sommeil par DPYD.

   En bref

   FRMPD2B, gène humain spécifique régulé par l’activité et l’expérience, favorise la morphogenèse des neurones corticaux et contribue à leur connectivité.

7. Apparenté Contexte plus large Pas pertinent

   Ubiquitin Proteasome System BTB-Adaptor Protein Insomniac Modifies Seizure Severity and Response to the Ketogenic Diet in a Drosophila Model of Mitochondrial Encephalomyopathy

   Keri J. Fogle, Brynn Urban, Dana M. Mumford et al. · 2026 · Genes · Pas encore résumé

   Cette étude examine Insomniac, les crises et la réponse au régime cétogène chez la drosophile, plutôt que DPYD et la myélinisation.

   Résumé scientifique

   Background/Objectives: The ubiquitin proteasome system (UPS) serves critical cellular homeostatic functions that contribute to neurological health, including neuronal metabolism, synaptic plasticity, and the molecular circadian clock. The UPS is tightly regulated to ensure the correct balance of healthy proteins and those targeted for degradation and recycling; malfunction in this quality control process can contribute to disease states such as neurodegeneration and cancer. Target specificity in this system is due in part to ubiquitin ligase adaptor proteins, such as those of the BTB superfamily of proteins, which connect substrates to the larger proteasomal complex. In Drosophila, the BTB f…

8. Apparenté Contexte plus large Pas pertinent

   Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea

   Michael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour et al. · 2026 · Glia · Pas encore résumé

   Cette étude analyse les altérations gliales dans un modèle murin d’apnée obstructive pédiatrique et leurs liens avec la mémoire, non la régulation du sommeil par DPYD.

   Résumé scientifique

   Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant brain development and cognitive deficits. The pathophysiological underpinnings of cognitive impairments in POSA remain unclear. Here, we examined cellular and molecular aspects of pathology in a mouse model of POSA that features learning and memory deficits. We performed single‐nucleus RNA‐sequencing (snRNA‐seq) of the hippocampus to examine gene expression changes in an unbiased and cell type‐specific manner. This dataset revealed a striking perturbation of transcriptomes across all brain cell types, particularly within glia and neural stem cells. We validated reduced expression of several diff…