Visual experience-driven switch in endothelial metabolic transporters is essential for cerebrovascular maturation

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1. Proche Même question Pas pertinent

   Ligand-specific endothelial Notch signaling coordinates brain pericyte specification and expansion

   Hua-Xing Zi, C. Dang, Wei-Yi Sima et al. · 2026 · bioRxiv · preprint, non relu par les pairs · Pas encore résumé

   L’étude examine comment des signaux endothéliaux coordonnent le développement vasculaire cérébral, ici la spécification et l’expansion des péricytes par Notch.

   Résumé scientifique

   Pericyte specification and expansion must be coordinated with vascular growth to establish a functional cerebrovascular network, yet how endothelial signals control these distinct developmental transitions remains incompletely understood. Here, using genetic manipulation, single-cell transcriptomic analysis, and longitudinal in vivo imaging in zebrafish, we identify ligand-specific endothelial Notch signaling as a mechanism coordinating brain pericyte development. Endothelial Jag2b is required for efficient pericyte specification from pericerebral progenitor pools and subsequently promotes Notch-dependent pericyte proliferation and population expansion. By contrast, endothelial Dll4 restrain…

2. Proche Contexte plus large Pas pertinent

   EXPRESS: Targeting the Neurovascular Interface: Endothelial Optogenetics as a New Frontier for Brain Circuit Interrogation.

   Shu-Min Gong, Ye Liao, Jia-Le Ye et al. · 2026 · Journal of Cerebral Blood Flow and Metabolism · Pas encore résumé

   Cet article présente l’optogénétique endothéliale pour étudier les fonctions propres de l’endothélium cérébral, plutôt que sa maturation développementale.

   Résumé scientifique

   The advent of optogenetics has revolutionized neuroscience by enabling precise manipulation of neural circuits, solidifying a neuron-centric view of brain function. This perspective has increasingly expanded to encompass non-neuronal cells, with the optogenetic control of astrocytes, microglia, and pericytes revealing their active roles in information processing. Yet the vascular endothelium long regarded as a passive conduit has remained largely unexplored through this lens. Here we discuss the emerging field of endothelial optogenetics, which seeks to isolate the cell-autonomous signaling capacity of brain endothelial cells, distinct from their hemodynamic functions. We explore the hypothe…

3. Proche Contexte plus large Pas pertinent

   Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

   Kayoung Han, M. Jang, Taeyoung Park et al. · 2026 · Advancement of science · Pas encore résumé

   L’étude relie la stimulation sensorielle aux réponses astrocytaires et vasculaires, mais porte sur le couplage neurovasculaire aigu plutôt que sur la maturation.

   Résumé scientifique

   ABSTRACT Astrocytes are recognized as key components of neurovascular coupling (NVC), yet whether and how astrocytic engagement in NVC depends on sensory stimulus duration remains unclear. Here, we investigated a duration‐dependent astrocytic mechanism underlying cerebral blood volume (CBV) modulation by comparing neurovascular responses to brief (5 s) and prolonged (20 s) sensory stimulation, using in vivo intrinsic optical signal (IOS) imaging and two‐photon microscopy combined with electrophysiology and vascular cannulation. We show that prolonged stimulation selectively recruits an integrated astrocytic signaling cascade involving aquaporin‐4 (AQP4)‐mediated volume changes, Ca2+ influx t…

4. Proche Contexte plus large Pas pertinent

   EXPRESS: Brain pericytes bridge and constrict capillaries in a streptozotocin diabetes mouse model.

   Kareem El-Ghazawi, Yashasvisai Veeramasu, Gabrielle E Largoza et al. · 2026 · Journal of Cerebral Blood Flow and Metabolism · Pas encore résumé

   L’étude caractérise les changements des péricytes et des capillaires cérébraux dans le diabète précoce, non le développement vasculaire postnatal.

   Résumé scientifique

   Diabetes is an established driver of microvascular disease, causing complications such as retinopathy, nephropathy, and neuropathy. However, the mechanisms whereby diabetes disrupts brain microvascular function remain poorly understood. Diabetes is strongly associated with cognitive impairments, including Alzheimer's Disease (AD), in which pericyte pathology is implicated in cerebrovascular dysfunction. Pericytes are critical regulators of blood-brain barrier integrity and capillary blood flow, yet their behavior during early diabetes remains uncharacterized. Using a 14-day streptozotocin (STZ) mouse model of early hyperglycemia, we demonstrate two distinct phenotypic changes in the brain pr…

5. Proche Article de revue Pas pertinent

   Immune-endothelial crosstalk at the nexus of neuroinflammation and vascular dysfunction in aging

   Zhi-Tao Cui, Huai-Yu Sun, Zhi-Qing Chen et al. · 2026 · Frontiers in Immunology · Pas encore résumé

   Cette revue synthétise les interactions immunitaires et endothéliales associées au vieillissement et au dysfonctionnement vasculaire cérébral.

   Résumé scientifique

   Aging is the major biological risk factor for cognitive decline and neurodegenerative disease. Increasing evidence indicates that neuroinflammation and cerebrovascular dysfunction are not independent consequences of aging but interact through the neurovascular interface. Cerebrovascular endothelial cells are central to this interaction because they form the blood–brain barrier (BBB) while actively regulating vascular tone, molecular transport, leukocyte trafficking, and inflammatory signaling. Here, we review how aging simultaneously primes immune and endothelial compartments through microglial sensitization, astrocytic remodeling, systemic inflammaging, endothelial senescence, altered trans…

6. Proche Article de revue Pas pertinent

   Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities

   Meng-Jie Zhang, Xue-Ying Huang, Lin Yao et al. · 2026 · Frontiers in Cellular Neuroscience · Pas encore résumé

   Cette revue examine les fonctions endothéliales cérébrales et leurs liens avec les troubles psychiatriques, plutôt que la maturation de la barrière.

   Résumé scientifique

   Brain endothelial cells (BECs) are specialized components of the neurovascular unit that couple circulating signals to cerebral blood flow regulation, blood–brain barrier (BBB) function, and selective molecular transport. This narrative review evaluates the correlation of these endothelial functions with psychiatric disorders, including depression and schizophrenia, distinguishing established vascular physiology from disease-specific evidence. In neurovascular coupling, the functions of capillary Kir2.1/phosphatidylinositol 4,5-bisphosphate and ATP-sensitive K+ channels, TRPA1-PANX1-P2X signaling, inositol 1,4,5-trisphosphate receptor-mediated Ca2+ events, arterial GJA4/GJA5 coupling, and PI…

7. Proche Article de revue Pas pertinent

   Thyroid hormones and neurovascular development: An integrated framework.

   I. Ochando, D. Navarro · 2026 · Frontiers in neuroendocrinology (Print) · Pas encore résumé

   Cette synthèse traite des hormones thyroïdiennes dans le développement neurovasculaire, notamment leurs effets sur l’angiogenèse et les astrocytes.

   Résumé scientifique

   Thyroid hormones (THs) are essential regulators of brain development known for their roles in neuronal proliferation, migration, differentiation, and maturation. However, brain development relies on coordinated interactions among neural, glial, vascular, and extracellular matrix components, supporting a broader role for TH beyond neuronal effects. Here, we examine how spatial regulation of TH availability contributes to neurovascular development by integrating findings from developmental animal models, human fetal tissue, cerebral organoids, and TH transport disorders. We discuss the molecular mechanisms controlling TH availability and examine how TH signaling influences angiogenesis, astroc…

8. Proche Même méthode, autre problème Pas pertinent

   Endothelial Malat1 promotes post-stroke angiogenesis and neurovascular recovery via the Tek axis.

   Tian-Qing Xiong, Meng-Qi Zhang, Ping Sun et al. · 2026 · Brain : a journal of neurology · Pas encore résumé

   L’étude manipule un régulateur endothélial pour examiner l’angiogenèse cérébrale, mais dans la réparation vasculaire après un AVC.

   Résumé scientifique

   Ischemic stroke remains a leading cause of mortality and disability worldwide, yet current therapeutic strategies, such as thrombolysis and thrombectomy, are constrained by narrow treatment windows and incomplete microvascular repair. While angiogenesis is pivotal for long-term functional recovery, the epigenetic mechanisms governing post-stroke vascular remodeling remain poorly understood. Here, we demonstrate that the long non-coding RNA (lncRNA) Malat1 acts as a critical endothelial regulator of angiogenesis and neurological restoration. Using an endothelium-specific Malat1 overexpression mouse model (EC-Malat1 Tg), we demonstrate endothelial Malat1 upregulation enhances angiogenesis, res…