Pulmonary colonization of Candida albicans drives breast cancer lung metastasis via candidalysin

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1. Très proche Article de revue Pas pertinent

   Complex Interrelationships Between Tumors, the Mycobiota, and Systemic Chemotherapy

   O. Zolotukhin, Y. Konechnyi, V. Havryliak et al. · 2026 · Microorganisms · Pas encore résumé

   Cette revue synthétise les interactions entre mycobiote tumoral, progression cancéreuse et traitements, dont l’étude examine un exemple dans les métastases pulmonaires.

   Résumé scientifique

   The fungal microbiome is an increasingly recognized component of the tumor microenvironment, yet its interactions with cancer development and systemic anticancer therapy remain poorly characterized. This review summarizes current evidence on the role of fungi in tumors and their interactions with systemic chemotherapy and antifungal therapy. We discuss potential mechanisms by which the mycobiota may contribute to oncogenesis through immune modulation, remodeling of the tumor microenvironment, chronic inflammation, angiogenesis, and other tumor-supportive processes. We further examine evidence that several anticancer agents, including doxorubicin, cisplatin, and bleomycin, exhibit antifungal …

2. Proche Article de revue Pas pertinent

   Gut mycobiome dysbiosis in digestive system cancers: immune remodeling and translational implications

   Lin Ma, Zhen Wang, Jie Mao · 2026 · Frontiers in Cellular and Infection Microbiology · Pas encore résumé

   Cette revue examine la dysbiose fongique digestive et ses effets immunitaires, tandis que l’étude porte sur Candida albicans dans les métastases pulmonaires du cancer du sein.

   Résumé scientifique

   Fungal dysbiosis has been reported in colorectal cancer (CRC), gastric cancer (GC), and pancreatic ductal adenocarcinoma (PDAC), but evidence strength differs substantially by tumor type and model system. Human CRC studies provide the broadest ecological evidence, including altered fungal community structure and fungal-bacterial networks. Human GC evidence is mainly cross-sectional and identifies Candida albicans as a candidate tissue-associated signal rather than a proven driver. In PDAC, human tissue studies report fungal signals, whereas causal support for Malassezia–mannose-binding lectin (MBL)–complement and fungal IL-33/type 2 immunity derives principally from mouse perturbation models…

3. Proche Article de revue Pas pertinent

   The CCL2-CCR2 axis in primary lung cancer and pulmonary metastasis: from molecular mechanisms to therapeutic potentials

   Yu-Jie Huang, Jia Ma, J. Bi et al. · 2026 · Frontiers in Immunology · Pas encore résumé

   Cette revue décrit comment l’axe CCL2–CCR2 recrute des cellules immunosuppressives et favorise les métastases, mécanisme voisin du remodelage immunitaire étudié.

   Résumé scientifique

   Lung cancer remains the leading cause of cancer-related mortality worldwide, with metastasis, therapeutic resistance, and an immunosuppressive TME representing major barriers to successful treatment. Among the chemokine signaling networks implicated in these processes, the CCL2–CCR2 axis has emerged as an important regulator of tumor progression. By orchestrating the recruitment of monocytes, tumor-associated macrophages, myeloid-derived suppressor cells, and other stromal components, this pathway can establish an immune-permissive niche that supports angiogenesis, epithelial–mesenchymal transition, extracellular-matrix remodeling, metastatic dissemination, and resistance to chemotherapy, ta…

4. Proche Article de revue Pas pertinent

   Intratumoral Microbiome–Tumor Microenvironment Crosstalk in Breast Cancer Aggressiveness

   O. Mushii, Ye Lukianova, V. Bazas · 2026 · The Breast Journal · Pas encore résumé

   Cette revue traite des liens entre microbiome intratumoral et agressivité du cancer du sein, tandis que l’étude analyse Candida albicans dans ses métastases pulmonaires.

   Résumé scientifique

   Breast cancer (BC) remains the most common malignancy among women worldwide, with incidence and mortality rates continuing to rise. Alongside tumor heterogeneity and diverse clinical outcomes, increasing attention has been directed toward the role of the intratumoral microbiome as a regulator of breast tumorigenesis. Recent evidence demonstrates that breast tissue harbors one of the most diverse microbial communities compared with other cancer types, with marked differences between normobiota and malignant tissue. Intratumoral microorganisms are potentially associated with BC progression through multiple mechanisms, including modulation of inflammation, steroid hormone metabolism, and extrac…

5. Proche Même question Pas pertinent

   Oral Fungal Infection Impacts Epithelial Innate Immunity to Promote Local and Distal Squamous Cell Carcinoma Progression

   Xin Li, A. K. Singh, Na-Young Song et al. · 2026 · Cancer Research · cité 1 fois · Pas encore résumé

   Cette étude montre qu’une infection fongique orale favorise la progression locale et distante d’un carcinome épidermoïde, comme l’étude examine un effet fongique sur les métastases.

   Résumé scientifique

   Fungi have been detected within human tumors and shown to support tumor progression. A better understanding of how intratumoral fungi evade innate immunity, remodel the tumor microenvironment (TME), and promote tumorigenesis may provide insights into cancer pathogenesis and therapeutic strategies. Here, we showed that aggressive human head and neck squamous cell carcinomas (HNSCCs) harbor an elevated fungal burden, including the environmental fungus Cladosporium cladosporioides, and are infiltrated by IL1B-high neutrophils with impaired reactive oxygen species (ROS) production and phagocytosis, as well as IL1B-high macrophages. In a mouse model in which Ikka ablation drives tumorigenesis thr…

6. Proche Article de revue Pas pertinent

   Candida albicans in oral squamous cell carcinoma: a review of mechanistic pathways and clinical translational strategies

   Pei-Ning Zheng, Qing-Qi Xie, Kenneth K. Y. Cheng et al. · 2026 · Frontiers in Cellular and Infection Microbiology · Pas encore résumé

   Cette revue évalue les mécanismes et les preuves reliant Candida albicans au carcinome épidermoïde oral, alors que l’étude teste son rôle causal dans les métastases mammaires.

   Résumé scientifique

   Oral squamous cell carcinoma (OSCC) develops within a complex mucosal ecosystem in which microbial dysbiosis, epithelial injury, inflammation, and immune remodeling interact with established carcinogenic exposures. Although Candida albicans has repeatedly been associated with OSCC and oral potentially malignant disorders (OPMDs), its causal and translational significance remains uncertain. This review critically evaluates clinical, microbiological, mechanistic, and translational evidence, with particular attention to the distinction between association, biological plausibility, and causal inference. Current evidence is more consistent with context-dependent tumor-promoting activity than with…

7. Proche* Même méthode, autre problème Pas pertinent

   Candida albicans promotes self-adhesion and tumor cell progression of colorectal cancer cells

   Janet F. Staab, Olivia K. A. Paulin, J. Naglik et al. · 2026 · bioRxiv · preprint, non relu par les pairs · Pas encore résumé

   Cette étude examine les effets de Candida albicans sur l’adhésion et la progression de cellules cancéreuses colorectales, comme l’étude teste les effets tumoraux du champignon.

8. Proche Article de revue Pas pertinent

   The intratumoral microbiome in breast cancer: an actionable component of the tumor immune microenvironment

   Chiara Cossu, Manuel Adamo, Antonino Di Lorenzo et al. · 2026 · Frontiers in Immunology · Pas encore résumé

   Cette revue synthétise le rôle du microbiome intratumoral dans le cancer du sein, un cadre auquel l’étude ajoute la colonisation fongique pulmonaire.

   Résumé scientifique

   Breast cancer remains one of the leading causes of cancer-related deaths in women. The discovery of a breast tumor microbiota has deeply changed our understanding of the breast tumor microenvironment, identifying microorganisms as active players in tumor progression. Increasing evidence suggests that intratumoral bacteria may influence multiple hallmarks of breast cancer, including chronic inflammation, immune modulation, metabolic reprogramming, epithelial plasticity, metastatic dissemination, and therapeutic response. Distinct microbial communities have been associated with specific breast cancer subtypes and clinical outcomes, and some mechanistic studies have demonstrated that individual…