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Résumé : A comparison has been made of the metabolism of cis,cis-linoleic, trans,trans-linoleic, and a mixture of cis,trans- and trans,cis-linoleic acids in the rat. The data show that linoleic acid and its geometric isomers were well absorbed. These acids were readily oxidized to CO2 with no apparent difference in rate or extent of catabolism between the trans-isomers. However, the trans-isomers of linoleic acid were catabolized to CO2 to a somewhat greater extent than was cis,cis-linoleic acid. Although these differences were small, they are consistent with the fact that the geometric isomers have no essential fatty acid activity and, therefore, might conceivably be more available as an energy source than the cis,cis-isomer. The trans-linoleic acids, like the cis,cis-linoleic acid, were transported in the lymph mainly as glycerides. There were no major differences in the distribution of the various acids among the lymph lipid classes, indicating that the rat does not distinguish among the linoleic acid isomers as far as digestion and absorption are concerned. Linoleic acid and its trans-isomers were metabolized in an efficient and apparently normal manner.