Exécution de notre outil de synthèse sur un nouvel article

Vérifiez l’article ci-dessous, puis lancez sa synthèse.


Flow Hydrodediazoniation of Aromatic Heterocycles

Liesa Röder (Freie Universität Berlin), Alexander J. Nicholls (Durham University), Ian R. Baxendale (Durham University)

Molecules
Licence : CC BY

Résumé : Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimised to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines, to be deaminated in good yield using a purely organic-soluble system.

Publié le 24 Mai. 2019