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microRNAs in nociceptive circuits as predictors of future clinical applications
Michaela Kress (Innsbruck Medical University, Universität Innsbruck), Alexander Hüttenhofer (Innsbruck Medical University), Marc Landry (Centre National de la Recherche Scientifique, Université de Bordeaux), Rohini Kuner (Heidelberg University), Alexandre Favereaux (Centre National de la Recherche Scientifique, Université de Bordeaux), David Greenberg (Hebrew University of Jerusalem), Josef Bednařík (University Hospital Brno), Paul A. Heppenstall (European Molecular Biology Laboratory), Florian Kronenberg (Innsbruck Medical University), Marzia Malcangio (King's College London), Heike Lydia Rittner (Universitätsklinikum Würzburg), Nurcan Üçeyler (Universitätsklinikum Würzburg), Zlatko Trajanoski (Innsbruck Medical University), Peter Mouritzen, Frank Birklein (University Medical Center of the Johannes Gutenberg University Mainz), Claudia Sommer (Universitätsklinikum Würzburg), Hermona Soreq (Hebrew University of Jerusalem)
Résumé : Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs - and microRNAs (miRNAs) in particular - regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief. Furthermore, predisposing miRNA expression patterns and inter-individual variations and polymorphisms in miRNAs and/or their binding sites may serve as biomarkers for pain and help to predict individual risks for certain types of pain and responsiveness to analgesic drugs. miRNA-based diagnostics are expected to develop into hands-on tools that allow better patient stratification, improved mechanism-based treatment, and targeted prevention strategies for high risk individuals.