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From phenomenon to mechanism in the circadian clock of Synechococcus elongatus

Susan S. Golden (University of California San Diego)

npj Biological Timing and Sleep
Licence : CC BY-NC-ND

Résumé : Creative and collaborative research in the early 21st century revealed the mechanistic secrets of the cyanobacterial circadian clock, a nanomachine whose function can be studied in vitro. The structural dynamics of the Synechococcus elongatus circadian oscillator, comprising KaiA, KaiB, and KaiC, establish a near 24 h cycle of activity of the global transcription regulator RpaA by rhythmically changing the interaction platform of kinases that control RpaA phosphorylation.

Publié le 29 Sep. 2026