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Photostimulation of cerebral and peripheral lymphatic functions
Oxana V. Semyachkina-Glushkovskaya (Saratov State University), Arkady Sergeevich Abdurashitov (Saratov State University), Maria Klimova (Saratov State University), Alexander I. Dubrovsky (Saratov State University), Alexander A. Shirokov (Russian Academy of Sciences, Institute of Biochemistry and Physiology of Plants and Microorganisms), Alexander S. Fomin (Russian Academy of Sciences, Institute of Biochemistry and Physiology of Plants and Microorganisms), Andrey V. Terskov (Saratov State University), Ilana Agranovich (Saratov State University), Мамедова Айсель Тофик-Кызы (Saratov State University), Aleksandr P. Khorovodov (Saratov State University), Valeria Telnova (Saratov State University), Блохина Инна Андреевна (Saratov State University), Nikita Lezhnev (Saratov State University), Ali Esmat Shareef (Saratov State University), Anna Kuzmina (Saratov State University), Sergei G. Sokolovski (Saratov State University, Aston University), Valery Victorovich Tuchin (Saratov State University, National Research Tomsk State University), Рафаилов Эдик Урихаевич (Saratov State University, Aston University), Jürgen Kurths (Saratov State University, Humboldt-Universität zu Berlin)
Résumé : Abstract The recently rediscovered meningeal lymphatic system (MLS) opens new insight into pathways of brain clearing and drainage functions that play an important role in neurorehabilitation. The development of breakthrough strategies for augmentation of MLS might be a promising therapeutic target for preventing of neurological diseases. Here we demonstrate photostimulation (PS, 1268 nm) of clearing and drainage function of MLS in healthy male mice. We uncover PS‐mediated increase of the mesenteric lymphatic permeability to fluorescent macrophages via a decrease of expression of tight junction and transendothelial resistance. In sum, our results clearly show PS stimulation of meningeal clearing and drainage functions as well as effects of PS on permeability of the lymphatic endothelium to macrophages. These findings open new strategies for alternative nonpharmacological therapy of brain diseases via PS modulation of lymphatic mechanisms of the homeostasis of central nervous system.