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A decay‐modeled compressed sensing reconstruction approach for non‐Cartesian hyperpolarized 129Xe MRI
Joseph W. Plummer (Cincinnati Children's Hospital Medical Center, University of Cincinnati), Riaz Hussain (Cincinnati Children's Hospital Medical Center), Abdullah S. Bdaiwi (Cincinnati Children's Hospital Medical Center, University of Cincinnati), Stephanie A. Soderlund (Cincinnati Children's Hospital Medical Center, University of Cincinnati), X. Hoyos Cordon (Cincinnati Children's Hospital Medical Center, University of Cincinnati), John M. Lanier (Cincinnati Children's Hospital Medical Center), William J. Garrison (Cincinnati Children's Hospital Medical Center), Juan Parra‐Robles (Cincinnati Children's Hospital Medical Center), Matthew M. Willmering (Cincinnati Children's Hospital Medical Center), Peter J. Niedbalski (University of Kansas Medical Center), Zackary I. Cleveland (Cincinnati Children's Hospital Medical Center, University of Cincinnati), Laura L. Walkup (Cincinnati Children's Hospital Medical Center, University of Cincinnati)
Résumé : PURPOSE: Xe MRI benefits from non-Cartesian acquisitions that sample k-space efficiently and rapidly. However, their reconstructions are complex and burdened by decay processes unique to hyperpolarized gas. Currently used gridded reconstructions are prone to artifacts caused by magnetization decay and are ill-suited for undersampling. We present a compressed sensing (CS) reconstruction approach that incorporates magnetization decay in the forward model, thereby producing images with increased sharpness and contrast, even in undersampled data. METHODS: decay processes were incorporated into the forward model and solved using iterative methods including CS. The decay-modeled reconstruction was validated in simulations and then tested in 2D/3D-spiral ventilation and 3D-radial gas-exchange MRI. Quantitative metrics including apparent-SNR and sharpness were compared between gridded, CS, and twofold undersampled CS reconstructions. Observations were validated in gas-exchange data collected from 15 healthy and 25 post-hematopoietic-stem-cell-transplant participants. RESULTS: CS reconstructions in simulations yielded images with threefold increases in accuracy. CS increased sharpness and contrast for ventilation in vivo imaging and showed greater accuracy for undersampled acquisitions. CS improved gas-exchange imaging, particularly in the dissolved-phase where apparent-SNR improved, and structure was made discernable. Finally, CS showed repeatability in important global gas-exchange metrics including median dissolved-gas signal ratio and median angle between real/imaginary components. CONCLUSION: Xe decay processes is presented. This approach enables improved image sharpness, contrast, and overall image quality in addition to up-to threefold undersampling. This contribution benefits all hyperpolarized gas MRI through improved accuracy and decreased scan durations.