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Résumé : Procedures were developed for degrading bulk amounts of pharmaceuticals in research laboratories. Pharmaceutical compounds are designed to achieve the maximum biological effect per gram, so it seems a reasonable proposition that a degradation reaction will produce compounds of lesser biological activity. Pharmaceuticals can be degraded by potassium permanganate in acidic, basic, or neutral solution. Nickel–aluminum alloy in an aqueous base is a powerful reductant that cleaves N–N, N–O, and carbon–halogen bonds. In all cases, destruction was greater than 99.8% except for pharmaceutical preparations of mechlorethamine. A variety of pharmaceuticals in aqueous solutions can be degraded using ozonation. Potassium ferrate is a powerful oxidizing agent. Pharmaceuticals can be degraded using persulfates. In all cases, destruction was greater than 99.8% except for pharmaceutical preparations of mechlorethamine. This chapter focuses on the photolysis of pharmaceuticals without the presence of hydrogen peroxide.